A well-built clinical question is directly relevant to patient care and helps guide searching for evidence-based answers. There are generally four components of a good clinical question and they are represented by the acronym PICO.
P - Patient, population or problem of interest
I - Intervention - therapy, diagnostic test, exposure, etc.
C - Comparison intervention, if relevant
O - Outcome(s) of interest
For example, you might start by wondering, "What's the best form of birth control?" But "best" is subjective - you'll need to restate your question in the PICO format to get a clincal answer.
The PICO format will help you translate your question from an initial broad topic,or specific patient's experience, to a concrete, objective question that you can find clinical evidence to answer.